Dr. Kishore A Krishnamurthy

Assistant Professor

About

I am Dr. Kishore, originally from Thirthahalli. My career started in a small town, driven by a great passion for science. I have a broad spectrum of experience, spanning from teaching high school students to conducting high-quality research. Moving across the borders to pursue my passion for science is the driving motivation. I have accomplished excellent research experience and am willing to contribute further to society in my current role at RV University, Mysore.

Teaching and Research: I have 2 years of academic teaching experience before I began my research career. I am a biochemistry expert with a great interest in metabolism and metabolic diseases.

“Be less curious about people and more about ideas” - Madame Curie

Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice. Kishore A. Krishnamurthy, Ruiqi Xiao, Martijn G.S. Rutten, Trijnie Bos, Aycha Bleeker, Mingjia Zhang, Hilda I. de Vries, Mirjam Koster, Nicolette Huijkman, Marieke Smit, Niels Kloosterhuis, Theo Boer, Bauke Schomakers, Michel van Weeghel, Bart van de Sluis , Justina C. Wolters, Barbara M. Bakker, Maaike H. Oosterveer

Link: https://doi.org/10.1016/j.molmet.2026.102393

Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models Kishore A. Krishnamurthy, Jack Leslie, Indresh K. Gopalsamy, Patricia Inacio, Meritxell Huch, Suchira Gallage, Fiona Oakley & Michele Vacca

Link: https://doi.org/10.1038/s41575-025-01162-9

Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production Kishore Alagere Krishnamurthy, Ligia Akemi Kiyuna, Esther B. Homan, Miriam Langelaar-Makkinje, Albert Gerding, Trijnie Bos, Dorenda Oosterhuis, Ruben J. Overduin, Andrea B. Schreuder, Vincent E. de Meijer, Peter Olinga, Terry G. J. Derks, Karen van Eunen, Barbara M. Bakker & Maaike H. Oosterveer

Link: https://doi.org/10.1038/s42003-024-07070-z

Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib K.A. Krishnamurthy , M.G.S. Rutten , J.A. Hoogerland, T.H. van Dijk, T. Bos, M. Koehorst, M.P. de Vries, N.J. Kloosterhuis, H. Havinga, B.V. Schomakers , M. van Weeghel, J.C. Wolters, B.M. Bakker, M.H. Oosterveer

Link: https://doi.org/10.1016/j.molmet.2023.101838

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings, Alain de Bruin, Bart van de Sluis & Maaike H. Oosterveer

Link: https://doi.org/10.1186/s40170-023-00305-3

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a Anouk M. La Rose, Anouk G. Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, Kishore A. Krishnamurthy, Mirjam H. Koster, Niels J. Kloosterhuis, Marieke Smit, Rick Havinga, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer, Marit Westerterp

Link: https://doi.org/10.1016/j.ymgmr.2022.100872

Rare genetic diseases, liver metabolism, metabolic diseases – diabetes, fatty liver disease, obesity, cell signaling (AMPK, ChREBP, autophagy)

Dr. Kishore is an accomplished preclinical researcher specializing in metabolic diseases, with a dedicated focus on conditions including MASLD, diabetes, and obesity. Over a distinguished decade-long career across global research hubs, he has developed extensive expertise in advancing biomedical research. His international journey includes 2 years of significant postdoctoral research experience at King’s College London and 5 years of PhD studies at the University of Groningen (The Netherlands).

As a rigorous academic, Dr. Kishore has made impactful contributions to the scientific community, notably serving as the first author on key publications exploring hepatic metabolism and glycogen storage disease. His publication achievements reflect a sophisticated ability to synthesize complex metabolic and genetic data into high-impact narratives. Deeply engaged in academic publishing and editorial strategy, he has worked across advanced therapeutics, targeted drug delivery, and neurobiology, bridging preclinical breakthroughs with rigorous peer-reviewed discourse for tier journals.

In 2026, after bringing his international insights back to India, he joined RV University’s Mysore campus as an Assistant Professor. In this role, he bridges the gap between cutting-edge metabolic research and higher-education leadership, integrating student-centric academic teaching.

Research Interests

Pre-clinical (partly clinical) research on metabolic diseases.

Dutch Liver Retreat – 3 February 2022 (Oral presentation)
Modelling hepatic Glycogen Storage Disease type 1 using Precision-Cut Liver Slices Opportunities, challenges, and open questions

PoLiMeR Final symposium - March-28 – March-31, 2022 (Poster Presentation)
Hepatic ChREBP knockdown aggravates hepatic glycogen accumulation and hypoglycemia while enhancing glycogen cycling in a mouse model for acute GSD Ib

European Association for the Study of Liver - June-22 - June-26, 2022 (Poster Presentation)
Precision-Cut Liver Slices as an ex vivo model to assess impaired hepatic glucose production

Dutch Translational Metabolism Conference (DTMC) – June 1 and 2 2023 (Oral presentation)
‘Hepatic ChREBP balances intrahepatic glucose and glycogen metabolism in a mouse model for acute Glycogen Storage Disease type Ib’

Grants
I am the first author in two grant applications during my PhD and was rewarded 10,000 EUR for my projects (DeCock Hadde)

Dr. Kishore A Krishnamurthy

Assistant Professor

PhD, Postdoctoral fellow

School of Pure and Applied Sciences

kishoreak@rvu.edu.in
Mysuru