Durgarao Guttula

Assistant Professor

About

Dr. Durgarao Guttula received his Master of Science in Physics from Banaras Hindu University in India. In 2010, he moved to Singapore to pursue a PhD in physics at the National University of Singapore, and he got his degree in 2014.

He was a postdoctoral fellow at the Singapore-MIT Alliance for Research and Technology (SMART) from 2014 to 2017 under the supervision of Professor Patrick Doyle (MIT). Later, he joined the Mechanobiology Institute (MBI), NUS, Singapore, where he worked under Professor Yan Jie. He conducted research on biomolecule force spectroscopy. He published seven articles in international journals with peer evaluation. In addition to his research, he worked as a safety manager for the lab for more than four years and as a fire warden for two years at NUS.

He spent nine months as an assistant professor at the Chaitanya Institute of Science and Technology teaching engineering physics to B.Tech. and diploma students before moving to RV University. He teaches Exploring Science to computer science students at RVU.

Take up an idea, devote yourself to it, struggle on in patience, and the sun will rise for you. ----- Swami Vivekananda

Guttula, D., Yao, M., Baker, K., Yang, L., Goult, B.T., Doyle, P.S., and Yan, J. (2019). Calcium- mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A. J Mol Biol 431, 433-443. doi:10.1016/j.jmb.2018.11.014

Guttula, D., Liu, F., van Kan, J.A., Arluison, V., and van der Maarel, J.R.C. (2018). Effect of HU protein on the conformation and compaction of DNA in a nanochannel. Soft Matter 14, 2322- 2328. doi:10.1039/c7sm02118f

van der Maarel, J.R., Guttula, D., Arluison, V., Egelhaaf, S.U., Grillo, I., and Forsyth, V.T. (2016). Structure of the H-NS-DNA nucleoprotein complex. Soft Matter 12, 3636-3642. doi:10.1039/c5sm03076e

Jiang, K., Zhang, C., Guttula, D., Liu, F., van Kan, J.A., Lavelle, C., Kubiak, K., Malabirade, A., Lapp, A., Arluison, V., et al. (2015). Effects of Hfq on the conformation and compaction of DNA. Nucleic Acids Res 43, 4332-4341. doi:10.1093/nar/gkv268

Zhang, C., Hernandez-Garcia, A., Jiang, K., Gong, Z., Guttula, D., Ng, S.Y., Malar, P.P., van Kan, J.A., Dai, L., Doyle, P.S., et al. (2013). Amplified stretch of bottlebrush-coated DNA in nanofluidic channels. Nucleic Acids Res 41, e189. doi:10.1093/nar/gkt783

Zhang, C., Guttula, D., Liu, F., Malar, P.P., Ng, S.Y., Dai, L., Doyle, P.S., van Kan, J.A., and van der Maarel, J.R. (2013). Effect of H-NS on the elongation and compaction of single DNA molecules in a nanospace. Soft Matter 9, 9593-9601. (Co-first author) doi:10.1039/c3sm51214b

Zhang, C., Gong, Z., Guttula, D., Malar, P.P., van Kan, J.A., Doyle, P.S., and van der Maarel, J.R. (2012). Nanouidic compaction of DNA by like-charged protein. J Phys Chem B 116, 3031- 3036. doi:10.1021/jp2124907

Research Summary: Mechanical stability of biofilm-associated proteins

A comparative study of the mechanical responses of Talin-1 and Talin-2

Role of mechanical forces on EGFR dimerization

Study the activation mechanism of receptor tyrosine kinases.

Single-DNA molecule conformational changes brought on by non-binding and nucleoid- associated proteins in nanospace

Distribution of bacterial architectural proteins H-NS and HU around the DNA by Small-Angle Neutron Scattering (SANS)

Normal mode analysis and DFT calculations of biomolecules

Research Interests:

Single-molecule force spectroscopy of biomolecules

Mechanobiology of human proteins

Mechanical response of biofilm-associated proteins

DNA-Nucleoid-Associated Protein Interaction Studies

Molecular dynamics simulations

Nano/microfluidic studies on biomolecules and epigenetics in lab-on-chip

National University of Singapore Graduate Research Scholarship: 2010

SIPIS: Summer Internship Programme for Indian Students, 2009

GATE-2009: Organised by IIT-Roorkee, Score: 95.73, Rank: 229, Qualified

Chess
Attended State Level Chess Tournament, Under-19 Years Boys & Girls 2003-04, conducted by Andhra Pradesh State School Games Federation, 2003.

National Service Scheme
Served at the NSS-Youth Campaign, conducted by Andhra University, 2004–05.

Durgarao Guttula

Assistant Professor

Ph.D

School of Computer Science and Engineering

durgaraog@rvu.edu.in
Bengaluru